Marine polyphenols have numerous dermatological benefits shown through scientific research.
- Natural UV damage defense and recovery
- Enhances skin structure: inhibits enzymes that degrade skin proteins such as elastase, hyaluronidase and matrix metalloproteinases
- Promotes hair growth
- Antimicrobial: inhibits bacteria and fungi that cause acne and skin troubles
- Anti-inflammatory: calms redness, itchiness and promotes healing
Sanjeewa KK, Kim EA, Son KT, Jeon YJ. Bioactive properties and potentials cosmeceutical applications of phlorotannins isolated from brown seaweeds: A review. J Phltochem Photobiol B (2016) 162:100-105.
Shin H, Cho AR, Kim DY, Munkhbayer A, Choi SJ, Jang S, Kim SH, Shin HC, Kwon O. Enhancement of human hair growth using Ecklonia cava polyphenols. Ann Dermatol (2016) 28:15-21.
Yang G, Oh JW, Lee HE, Lee BH, Lim KM, Lee JY. Topical application of dieckol ameliorates atopic dermatitis in NC/Nga mice by suppressing thymic stromal lymphopoietin production. J Invest Dermatol (2016) 136:1062-1066.
Ryu B, Ahn BN, Kang KH, Kim YS, Li YX, Kong CS, Kim SK, Kim DG. Dioxinodehydroeckol protects human keratinocyte cells from UVB-induced apoptosis modulated by related genes Bax/Bcl-2 and caspase pathway. J Photochem Photobiol B (2015) 153:352-357.
Choi JS, Lee K, Lee BB, Kim YC, Kim YD, Hong YK, Cho KK, Choi IS. Antibacterial activity of the phlorotannins dieckol and phlorofucofuroeckol-A from Ecklonia cava against Propipnibacterium acnes. Bot Sci (2014) 92:425-431.
Piao MJ, Ahn MJ, Kang KA, Kim KC, Zheng J, Yao CW, Cha JW, Hyun CL, Kang HK, Lee NH, Hyun JW. Phloroglucinol inhibits ultraviolet B radiation-induced oxidative stress in the mouse skin. Int J Radiat Biol (2014) 90:928-935.
Bak SS, Ahn BN, Kim JA, Shin SH, Kim JC, Kim MK, Sung YK, Kim SK. Ecklonia cava promotes hair growth. Clin Exp Dermatol (2013) 38:904-910.
Cha SH, Ko CI, Kim D, Jeon YJ. Protective effects of phlorotannins against ultraviolet B radiation in zebrafish (Danio rerio). Vet Dermatol (2012) 23:51-56.
Jang J, Ye BR, Heo SJ, Oh C, Kang DH, Kim JH, Affan A, Yoon KT, Choi YU, Park SC, Han S, Qian ZJ, Jung WK, Choi IW. Photo-oxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes. Environ Toxicol Pharmacol (2012) 34:926-934.
Kang JI, Kim SC, Kim MK, Boo HJ, Jeon YJ, Koh YS, Yoo ES, Kang SM, Kang HK. Effect of dieckol, a component of Ecklonia cava, on the promotion of hair growth. Int J Mol Sci (2012) 13:6407-6423.
Kang SM, Heo SJ, Kim KN, Lee SH, Yang HM, Kim AD, Jeon YJ. Molecular docking studies of a phlorotannin, dieckol isolated from Ecklonia cava with tyrosinase inhibitory activity. Bioorg Med Chem (2012) 20:311-316.
Lee MS, Yoon HD, Kim JI, Choi JS, Byun DS, Kim HR. Dioxinodehydroeckol inhibits melanin synthesis through PI3K/Akt signalling pathway in α-melanocyte-stimulating hormone-treated B16F10 cells. Exp Dermatol (2012) 21:471-473.
Piao MJ, Lee NH, Chae S, Hyun JW. Eckol inhibits ultraviolet B-induced cell damage in human keratinocytes via a decrease in oxidative stress. Biol Pharm Bull (2012) 35:873-880.
Cha SH, Ko SC, Kim D, Jeon YJ. Screening of marine algae for potential tyrosinase inhibitor: Those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish. J Dermatol (2011) 38:354-363.
Choi JS, Bae HJ, Kim SJ, Choi IS. In vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, Propionibacterium acnes. J Environ Biol (2011) 32:313-318.
Lee MH, Lee KB, Oh SM, Lee BH, Chee HY. Antifungal activities of dieckol isolated from the marine brown alga Ecklonia cava against Trichophyton rubrum. J Korean Soc Appl Biol Chem (2010) 53:504-507.
Heo SJ, Ko SC, Cha SH, Kang DH, Park HS, Choi YU, Kim D, Jung WK, Jeon YJ. Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation. Toxicol In Vitro (2009) 23:1123-1130.
Yoon NY, Eom TK, Kim MM, Kim SK. Inhibitory effect of phlorotannins isolated from Ecklonia cava on mushroom tyrosinase activity and melanin formation in mouse B16F10 melanoma cells. J Agric Food Chem (2009) 57:4124-4129.
Kang KA, Zhang R, Piao MJ, Ko DO, Wang ZH, Lee IK, Kim BJ, Shin T, Park JW, Lee NH, Yoo BS, Hyun JW. Inhibitory effects of triphlorethol-A on MMP-1 induced by oxidative stress in human keratinocytes via ERK and AP-1 inhibition. J Toxicol Environ Health A (2008) 7:992-999.
Bu HJ, Ham YM, Kim JM, Lee SJ, Hyun JW, Lee NH. Elastase and hyaluronidase inhibition activities of phlorotannins isolated from Ecklonia cava. Kor J Pharmacogn (2006) 37:92-96.
Hwang H, Chen T, Nines RG, Shin HC, Stoner GD. Photochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenols. Int J Cancer (2006) 119:2742-2749.
Joe MJ, Kim SN, Choi HY, Shin WS, Park GM, Kang DW, Kim YK. The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. Biol Pharm Bull (2006) 29:1735-1739.
Kim MM, Ta QV, Mendis E, Rajapakse N, Jung WK, Byun HG, Jeon YJ, Kim SK. Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity. Life Sci (2006) 79:1436-1443.
Kang HS, Kim HR, Byun DS, Son BW, Nam TJ, Choi JS. Tyrosinase inhibitors isolated from the edible brown alga Ecklonia stolonifera. Arch Pharm Res (2004) 27:1226-1232.
Kim JA, Lee JM, Shin DB, Lee NH. The antioxidant activity and tyrosinase inhibitory activity of phlorotannins in Ecklonia cava. Food Sci Biotech (2004) 13:476-480.
ShibataT, Fujimoto K, Nagayamak, Yamaguchi K, Nakamura T. Inhibitory activity of brown algal phlorotannins against hyaluronidase. Int J Food Sci Tech (2002) 37:703-709.