The balance between intake of energy sources (eating and digestion) and use of energy (cellular activity and physical exercise) is at the core of prevention and treatment of major chronic illnesses. Hypertension, type II diabetes, cardiovascular diseases and stroke can be controlled by maintaining this balance.

Mannas™ is a series of health supplements that target different steps of metabolism – nutrient absorption, digestion and cell activity – to prevent and alleviate diseases related to nutrition and obesity.

At the core, Mannas™ controls cholesterol and glucose levels in the blood, using potent bioactivity of natural marine polyphenols. The unique blend of marine polyphenols in Mannas™ has multiple benefits for the digestive system:

  • Anti-obesity effects from high-fat diet: alleviates abnormal metabolism and oxidative stress, inhibits fat accumulation, adipogenesis and lipogenesis
  • Type II diabetes: Reduces blood glucose levels after meals and improves insulin sensitivity
  • Prevents fatty liver and liver injury from high fat
  • Prevents diabetes complications (oxidative stress from high glucose levels)
  • Prevents liver injury from alcohol
  • Prevents kidney inflammation


Mannas™ All Digestion aid
Mannas™ Rice Controls carbohydrate absorption
Mannas™ Well Promotes nutrient use and protects digestive lining


Byun JH, Kim J, Choung SY. Hepaprotective effect of standardized Ecklonia stolonifera formulation on CCl4-induced liver injury in Sprague-Dawley rats. Biomol Ther (Seoul) (2018) 26:218-223.

Kim IH, Choi JW, Lee MK, Kwon CJ, Nam TJ. Anti-obesity effects of pectinase and cellulase enzyme‑treated Ecklonia cava extract in high‑fat diet‑fed C57BL/6N mice. Int J Mol Med (2018) 41:924-934.

Park SR, Kim JH, Jang HD, Yang SY, Kim YH. Inhibitory activity of minor phlorotannins from Ecklonia cava on α-glucosidase. Food Chem (2018) 257:128-134.

Eo H, Park JE, Jeon YJ, Lim Y. Ameliorative effect of Ecklonia cava polyphenol extract on renal inflammation associated with aberrant energy metabolism and oxidative stress in high fat diet-induced obese mice. J Agric Food Chem (2017) 65:3811-3818.

Kim IH, Nam TJ. Enzyme-treated Ecklonia cava extract inhibits adipogenesis through the downregulation of C/EBPα in 3T3-L1 adipocytes. Int J Mol Med (2017) 39:636-644.

Lee HA, Lee JH, Han JS. A phlorotannin constituent of Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice. Pharm Biol (2017) 55:1149-1154.

Lee JH, Jung HA, Kang MJ, Choi JS, Kim GD. Fucosterol, isolated from Ecklonia stolonifera, inhibits adipogenesis through modulation of FoxO1 pathway in 3T3-L1 adipocytes. J Pharm Pharmacol (2017) 69:325-333.

Yoon JY, Choi H, Jun HS. The effect of phloroglucinol, a component of Ecklonia cava extract, on hepatic glucose production. Mar Drugs (2017) 15:106.

Bang CY, Byun JH, Choi HK, Choi JS, Choung SY. Protective effects of Ecklonia stolonifera extract on ethanol induced fatty liver in rats. Biomol Ther (Seoul) (2016) 24:650-658.

Lee SY, Lee J, Lee H, Kim B, Lew J, Baek N, Kim SH. MicroRNA134 mediated upregulation of JNK and downregulation of NFκB signalings are critically involved in dieckol induced antihepatic fibrosis. J Agric Food Chem (2016) 64:5508-5514.

Takahashi M, Satake N, Yamashita H, Tamura A, Sasaki M, Matsui-Yuasa I, Tabuchi M, Akahoshi Y, Terada M, Kojima-Yuasa A. Ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats. Mar Drugs (2012) 13:3877-3891.

Choi HS, Jeon HJ, Lee OH, Lee BY. Dieckol, a major phlorotannin in Ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell-cycle arrest and AMPKα activation. Mol Nutr Food Res (2015) 59:1458-1471.

Eo H, Jeon YJ, Lee M, Lim Y. Brown alga Ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress and inflammation by activation of AMPK and SIRT1 in high fat diet-induced obese mice. J Agric Food Chem (2015) 63:349-359.

Jeon HJ, Choi HS, Lee YJ, Hwang JH, Lee OH, Seo MJ, Kim KJ, Lee BY. Seapolynol extracted from Ecklonia cava inhibits adipocyte differentiation in vitro and decreases fat accumulation in vivo. Molecules (2015) 20:21715-21731.

Jeon HJ, Yoon KY, Koh EJ, Choi J, Kim KJ, Choi HS, Lee BY. Seapolynol and dieckol improve insulin sensitivity through the regulation of the P I3K pathway in C57BL/KsJ-db/db mice. J Food Nutr Res (2015) 3:648-652.

Kwon TH, Wu YX, Kim JS, Woo JH, Park KT, Kwon OJ, Seo HJ, Kim T, Park NH. 6,6′-Bieckol inhibits adipocyte differentiation through downregulation of adipogenesis and lipogenesis in 3T3-L1 cells. J Sci Food Agric (2015) 95:1830-1837.

Lee SH, Jeon YJ. Efficacy and safety of a dieckol-rich extract (AG-dieckol) of brown algae, Ecklonia cava, in pre-diabetic individuals: a double-blind, randomized, placebo-controlled clinical trial. Food Funct (2015) 6:853-858.

Park EY, Choi H, Yoon JY, Lee IY, Seo Y, Moon HS, Hwang JH, Jun HS. Polyphenol-rich fraction of Ecklonia cava improves nonalcoholic fatty liver disease in high fat diet-fed mice. Mar Drugs (2015) 13:6866-6883.

You HN, Lee HA, Park MH, Lee JH, Han JS. Phlorofucofuroeckol A isolated from Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice. Eur J Pharmacol (2015) 752:92-96.

Jung HA, Jung HJ, Jeong HY, Kwon HJ, Ali MY, Choi JS. Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBPα and PPARγ. Fitoterapia (2014) 92:260-269.

Jung HA, Jung HJ, Jeong HY, Kwon HJ, Kim MS, Choi JS. Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes. Arch Pharm Res (2014) 37:713-720.

Jung HA, Kim JI, Choung SY, Choi JS. Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes. J Pharm Pharmacol (2014) 66:1180-1188.

Kang MC, Kim KN, Chaminda Lakmal HH, Kim EA, Wijesinghe WA, Yang X, Heo SJ, Jeon YJ. Octaphlorethol A isolated from Ishige foliacea prevents and protects against high glucose-induced oxidative damage in vitro and in vivo. Environ Toxicol Pharmacol (2014) 38:607-615.

Lee HA, Song YO, Jang MS, Han JS. Effect of Baechu Kimchi added Ecklonia cava extracts on high glucose-induced oxidative stress in human umbilical vein endothelial cells. Prev Nutr Food Sci (2014) 19:170-177.

Mori T, Hidaka M, Ikuji H, Yoshizawa I, Toyohara H, Okuda T, Uchida C, Asano T, Yotsu-Yamashita M, Uchida T. A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation. Biosci Biotechnol Biochem (2014) 78:832-838.

Park MH, Heo SJ, Park PJ, Moon SH, Sung SH, Jeon BT, Lee SH. 6,6′-Bieckol isolated from Ecklonia cava protects oxidative stress through inhibiting expression of ROS and proinflammatory enzymes in high-glucose-induced human umbilical vein endothelial cells. Appl Biochem Biotechnol (2014) 174:632-643.

Jung HA, Islam MN, Lee CM, Oh SH, Lee S, Jung JH, Choi JS. Kinetics and molecular docking studies of an anti-diabetic complication inhibitor fucosterol from edible brown algae Eisenia bicyclis and Ecklonia stolonifera. Chem Biol Interact (2013) 206:55-62.

Kang MC, Kim KN, Kang SM, Yang X, Kim EA, Song CB, Nah JW, Jang MK, Lee JS, Jung WK, Jeon YJ. Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model. Environ Toxicol Pharmacol (2013) 36:1217-1226.

Kang MC, Wijesinghe WA, Lee SH, Kang SM, Ko SC, Yang X, Kang N, Jeon BT, Kim J, Lee DH, Jeon YJ. Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model. Food Chem Toxicol (2013) 53:294-298.

Kang YM, Eom SH, Kim YM. Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells. Environ Toxicol Pharmacol (2013) 35:395-401.

Kim H, Kong CS, Lee JI, Kim H, Baek S, Seo Y. Evaluation of inhibitory effect of phlorotannins from Ecklonia cava on triglyceride accumulation in adipocyte. J Agric Food Chem (2013) 61:8541-8547.

Ko SC, Lee M, Lee JH, Lee SH, Lim Y, Jeon YJ. Dieckol, a phlorotannin isolated from a brown seaweed, Ecklonia cava, inhibits adipogenesis through AMP-activated protein kinase (AMPK) activation in 3T3-L1 preadipocytes. Environ Toxicol Pharmacol (2013) 36:1253-1260.

Lee HA, Song YO, Jang MS, Han JS. Alleviating effects of Baechu Kimchi added Ecklonia cava on postprandial hyperglycemia in diabetic mice. Prev Nutr Food Sci (2013) 18:163-168.

Dwiranti F, Hiraoka M, Taguchi T, Konishi Y, Tominaga M, Tominaga A. Effects of gametophytes of Ecklonia kurome on the levels of glucose and triacylglycerol in db/db, prediabetic C57BL/6J and IFN-γ KO mice. Int J Biomed Sci (2012) 8:64-75.

Eom SH, Lee MS, Lee EW, Kim YM, Kim TH. Pancreatic lipase inhibitory activity of phlorotannins isolated from Eisenia bicyclis. Phytother Res (2012) 27:148-151.

Eom SH, Lee SH, Yoon NY, Jung WK, Jeon YJ, Kim SK, Lee MS, Kim YM. α-Glucosidase- and α-amylase-inhibitory activities of phlorotannins from Eisenia bicyclis. J Sci Food Agric (2012) 92:2084-2090.

Kang MC, Ahn G, Yang X, Kim KN, Kang SM, Lee SH, Ko SC, Ko JY, Kim D, Kim YT, Jee Y, Park SJ, Jeon YJ. Hepatoprotective effects of dieckol-rich phlorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice. Food Chem Toxicol (2012) 50:1986-1991.

Kim HK. Ecklonia cava inhibits glucose absorption and stimulates insulin secretion in streptozotocin-induced diabetic mice. Evid Based Complement Alternat Med (2012) 2012:439294.

Kim MJ, Kim HK. Insulinotrophic and hypolipidemic effects of Ecklonia cava in streptozotocin-induced diabetic mice. Asian Pac J Trop Med (2012) 5:374-379.

Lee DH, Park MY, Shim BJ, Youn HJ, Hwang HJ, Shin HC, Jeon HK. Effects of Ecklonia cava polyphenol in individuals with hypercholesterolemia: A pilot study. J Med Food (2012) 15:1038-1044.

Lee MS, Kim JI, Utsuki T, Park NG, Kim HR. Cytoprotective effects of phlorofucofuroeckol A isolated from Ecklonia stolonifera against tacrine-treated HepG2 cells. Fitoterapia (2012) 83:1060-1067.

Lee MS, Shin TS, Utsuki T, Choi JS, Byun DS, Kim HR. Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tracrine-treated HepG2 cells. J Agric Food Chem (2012) 60:5340-5349.

Lee SH, Min KH, Han JS, Lee DH, Park DB, Jung WK, Park PJ, Jeon BT, Kim SK, Jeon YJ. Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus. Food Chem Toxicol (2012) 50:575-582.

Lee SH, Park MH, Kang SM, Ko SC, Kang MC, Cho S, Park PJ, Jeon BT, Kim SK, Han JS, Jeon YJ. Dieckol isolated from Ecklonia cava protects against high-glucose induced damage to rat insulinoma cells by reducing oxidative stress and apoptosis. Biosci Biotechnol Biochem (2012) 76:1445-1451.

Lee SH, Park MH, Park SJ, Kim J, Kim YT, Oh MC, Jeong Y, Kim M, Han JS, Jeon YJ. Bioactive compounds extracted from Ecklonia cava by using enzymatic hydrolysis protects high glucose-induced damage in INS-1 pancreatic β-cells. Appl Biochem Biotechnol (2012) 167:1973-1985.

Park EY, Kim EH, Kim MH, Seo YW, Lee JI, Jun HS. Polyphenol-rich fraction of brown alga Ecklonia cava collected from Gijang, Korea, reduces obesity and glucose levels in high-fat diet-induced obese mice. Evid Based Complement Alternat Med (2012) 2012:418912.

Shin HC, Kim SH, Park Y, Lee BH, Hwang HJ. Effects of 12-week oral supplementation of Ecklonia cava polyphenols on anthropometric and blood lipid parameters in overweight Korean individuals: A double-blind randomized clinical trial. Phytother Res (2012) 26(3:363-368.

Takahashi M, Satake N, Yamashita H, Tamura A, Sasaki M, Matsui-Yuasa I, Tabuchi M, Akahoshi Y, Terada M, Kojima-Yuasa A. Ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats. Biochim Biophys Acta (2012) 1820:978-988.

Xu HL, Kitajima C, Ito H, Miyazaki T, Baba M, Okuyama T, Okada Y. Antidiabetic effect of polyphenols from brown alga Ecklonia kurome in genetically diabetic KK-A(y) mice. Pharm Biol (2012) 50:393-400.

Yeo AR, Lee J, Tae IH, Park SR, Cho YH, Lee BH, Shin HC, Kim SH, Yoo YC. Anti-hyperlipidemic effect of polyphenol extract (Seapolynol™) and dieckol isolated from Ecklonia cava in in vivo and in vitro models. Prev Nutr Food Sci (2012) 17:1-7.

Kim SM, Kang K, Jeon JS, Jho EH, Kim CY, Nho CW, Um BH. Isolation of phlorotannins from Eisenia bicyclis and their hepatoprotective effect against oxidative stress induced by tert-butyl hyperoxide. Appl Biochem Biotechnol (2011) 165:1296-1307.

Moon HE, Islam N, Ahn BR, Chowdhury SS, Sohn HS, Jung HA, Choi JS. Protein tyrosine phosphatase 1B and α-glucosidase inhibitory phlorotannins from edible brown algae, Ecklonia stolonifera and Eisenia bicyclis. Biosci Biotechnol Biochem (2011) 75:1472-1480.

Yokogawa K, Matsui-Yuasa I, Tamura A, Terada M, Kojima-Yuasa A. Inhibitory effects of Ecklonia cava extract on high glucose-induced hepatic stellate cell activation. Mar Drugs (2011) 9:2793-2808.

Kang C, Jin YB, Lee H, Cha M, Sohn ET, Moon J, Park C, Chun S, Jung ES, Hong JS, Kim SB, Kim JS, Kim E. Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways. Food Chem Toxicol (2010) 48:509-516.

Kim SK, Kong CS. Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes. Chem Biol Interact (2010) 186:24-29.

Kong CS, Kim JA, Ahn BN, Vo TS, Yoon NY, Kim SK. 1-(3′,5′-dihydroxyphenoxy)-7-(2”,4”,6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin inhibits adipocyte differentiation of 3T3-L1 fibroblasts. Mar Biotechnol (NY) (2010) 12:299-307.

Lee SH, Park MH, Heo SJ, Kang SM, Ko SC, Han JS, Jeon YJ. Dieckol isolated from Ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice. Food Chem Toxicol (2010) 48:2633-2637.

Oh JK, Shin YO, Yoon JH, Kim SH, Shin HC, Hwang HJ. Effect of supplementation with Ecklonia cava polyphenol on endurance performance of college students. Int J Sport Nutr Exerc Metab (2010) 20:72-79.

Lee SH, Li Y, Karadeniz F, Kim MM, Kim SK. α-Glucosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga, Ecklonia cava. J Sci Food Agric (2009) 89:1552-1558.

Iwai K. Antidiabetic and antioxidant effects of polyphenols in brown alga Ecklonia stolonifera in genetically diabetic KK-Ay mice. Plant Foods Hum Nutr (2008) 63:163-169.

Yoon NY, Kim HR, Chung HY, Choi JS. Anti-hyperlipidemic effect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Arch Pharm Res (2008) 31:1564-1571.

Kim YC, An RB, Yoon NY, Nam TJ, Choi JS. Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in Hep G2 cells. Arch Pharm Res (2005) 28:1376-1380.

Okada Y, Ishimaru A, Suzuki R, Okuyama T. A new phloroglucinol derivative from the brown alga Eisenia bicyclis: Potential for the effective treatment of diabetic complications. J Nat Prod (2004) 67:103-105.

Shibata T, Yamaguchi K, Nagayama K, Kawaguchi S, Nakamura T. Inhibitory activity of brown algal phlorotannins against glycosidases from the viscera of the turban shell Turbo cornutus. Eur J Phycol (2002) 37:493-500.