The balance between intake of energy sources (eating and digestion) and use of energy (cellular activity and physical exercise) is at the core of prevention and treatment of major chronic illnesses. Hypertension, type II diabetes, cardiovascular diseases and stroke can be controlled by maintaining this balance.
Mannas™ is a series of health supplements that target different steps of metabolism – nutrient absorption, digestion and cell activity – to prevent and alleviate diseases related to nutrition and obesity.
At the core, Mannas™ controls cholesterol and glucose levels in the blood, using potent bioactivity of natural marine polyphenols. The unique blend of marine polyphenols in Mannas™ has multiple benefits for the digestive system:
- Anti-obesity effects from high-fat diet: alleviates abnormal metabolism and oxidative stress, inhibits fat accumulation, adipogenesis and lipogenesis
- Type II diabetes: Reduces blood glucose levels after meals and improves insulin sensitivity
- Prevents fatty liver and liver injury from high fat
- Prevents diabetes complications (oxidative stress from high glucose levels)
- Prevents liver injury from alcohol
- Prevents kidney inflammation
MANNAS™ PRODUCTS FOR GLUCOSE AND CHOLESTEROL CONTROL
|Mannas™ All||Digestion aid|
|Mannas™ Rice||Controls carbohydrate absorption|
|Mannas™ Well||Promotes nutrient use and protects digestive lining|
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Park SR, Kim JH, Jang HD, Yang SY, Kim YH. Inhibitory activity of minor phlorotannins from Ecklonia cava on α-glucosidase. Food Chem (2018) 257:128-134.
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Kim IH, Nam TJ. Enzyme-treated Ecklonia cava extract inhibits adipogenesis through the downregulation of C/EBPα in 3T3-L1 adipocytes. Int J Mol Med (2017) 39:636-644.
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Lee JH, Jung HA, Kang MJ, Choi JS, Kim GD. Fucosterol, isolated from Ecklonia stolonifera, inhibits adipogenesis through modulation of FoxO1 pathway in 3T3-L1 adipocytes. J Pharm Pharmacol (2017) 69:325-333.
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Bang CY, Byun JH, Choi HK, Choi JS, Choung SY. Protective effects of Ecklonia stolonifera extract on ethanol induced fatty liver in rats. Biomol Ther (Seoul) (2016) 24:650-658.
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Jung HA, Jung HJ, Jeong HY, Kwon HJ, Ali MY, Choi JS. Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBPα and PPARγ. Fitoterapia (2014) 92:260-269.
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Jung HA, Kim JI, Choung SY, Choi JS. Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes. J Pharm Pharmacol (2014) 66:1180-1188.
Kang MC, Kim KN, Chaminda Lakmal HH, Kim EA, Wijesinghe WA, Yang X, Heo SJ, Jeon YJ. Octaphlorethol A isolated from Ishige foliacea prevents and protects against high glucose-induced oxidative damage in vitro and in vivo. Environ Toxicol Pharmacol (2014) 38:607-615.
Lee HA, Song YO, Jang MS, Han JS. Effect of Baechu Kimchi added Ecklonia cava extracts on high glucose-induced oxidative stress in human umbilical vein endothelial cells. Prev Nutr Food Sci (2014) 19:170-177.
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Jung HA, Islam MN, Lee CM, Oh SH, Lee S, Jung JH, Choi JS. Kinetics and molecular docking studies of an anti-diabetic complication inhibitor fucosterol from edible brown algae Eisenia bicyclis and Ecklonia stolonifera. Chem Biol Interact (2013) 206:55-62.
Kang MC, Kim KN, Kang SM, Yang X, Kim EA, Song CB, Nah JW, Jang MK, Lee JS, Jung WK, Jeon YJ. Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model. Environ Toxicol Pharmacol (2013) 36:1217-1226.
Kang MC, Wijesinghe WA, Lee SH, Kang SM, Ko SC, Yang X, Kang N, Jeon BT, Kim J, Lee DH, Jeon YJ. Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model. Food Chem Toxicol (2013) 53:294-298.
Kang YM, Eom SH, Kim YM. Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells. Environ Toxicol Pharmacol (2013) 35:395-401.
Kim H, Kong CS, Lee JI, Kim H, Baek S, Seo Y. Evaluation of inhibitory effect of phlorotannins from Ecklonia cava on triglyceride accumulation in adipocyte. J Agric Food Chem (2013) 61:8541-8547.
Ko SC, Lee M, Lee JH, Lee SH, Lim Y, Jeon YJ. Dieckol, a phlorotannin isolated from a brown seaweed, Ecklonia cava, inhibits adipogenesis through AMP-activated protein kinase (AMPK) activation in 3T3-L1 preadipocytes. Environ Toxicol Pharmacol (2013) 36:1253-1260.
Lee HA, Song YO, Jang MS, Han JS. Alleviating effects of Baechu Kimchi added Ecklonia cava on postprandial hyperglycemia in diabetic mice. Prev Nutr Food Sci (2013) 18:163-168.
Dwiranti F, Hiraoka M, Taguchi T, Konishi Y, Tominaga M, Tominaga A. Effects of gametophytes of Ecklonia kurome on the levels of glucose and triacylglycerol in db/db, prediabetic C57BL/6J and IFN-γ KO mice. Int J Biomed Sci (2012) 8:64-75.
Eom SH, Lee MS, Lee EW, Kim YM, Kim TH. Pancreatic lipase inhibitory activity of phlorotannins isolated from Eisenia bicyclis. Phytother Res (2012) 27:148-151.
Eom SH, Lee SH, Yoon NY, Jung WK, Jeon YJ, Kim SK, Lee MS, Kim YM. α-Glucosidase- and α-amylase-inhibitory activities of phlorotannins from Eisenia bicyclis. J Sci Food Agric (2012) 92:2084-2090.
Kang MC, Ahn G, Yang X, Kim KN, Kang SM, Lee SH, Ko SC, Ko JY, Kim D, Kim YT, Jee Y, Park SJ, Jeon YJ. Hepatoprotective effects of dieckol-rich phlorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice. Food Chem Toxicol (2012) 50:1986-1991.
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Kim MJ, Kim HK. Insulinotrophic and hypolipidemic effects of Ecklonia cava in streptozotocin-induced diabetic mice. Asian Pac J Trop Med (2012) 5:374-379.
Lee DH, Park MY, Shim BJ, Youn HJ, Hwang HJ, Shin HC, Jeon HK. Effects of Ecklonia cava polyphenol in individuals with hypercholesterolemia: A pilot study. J Med Food (2012) 15:1038-1044.
Lee MS, Kim JI, Utsuki T, Park NG, Kim HR. Cytoprotective effects of phlorofucofuroeckol A isolated from Ecklonia stolonifera against tacrine-treated HepG2 cells. Fitoterapia (2012) 83:1060-1067.
Lee MS, Shin TS, Utsuki T, Choi JS, Byun DS, Kim HR. Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tracrine-treated HepG2 cells. J Agric Food Chem (2012) 60:5340-5349.
Lee SH, Min KH, Han JS, Lee DH, Park DB, Jung WK, Park PJ, Jeon BT, Kim SK, Jeon YJ. Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus. Food Chem Toxicol (2012) 50:575-582.
Lee SH, Park MH, Kang SM, Ko SC, Kang MC, Cho S, Park PJ, Jeon BT, Kim SK, Han JS, Jeon YJ. Dieckol isolated from Ecklonia cava protects against high-glucose induced damage to rat insulinoma cells by reducing oxidative stress and apoptosis. Biosci Biotechnol Biochem (2012) 76:1445-1451.
Lee SH, Park MH, Park SJ, Kim J, Kim YT, Oh MC, Jeong Y, Kim M, Han JS, Jeon YJ. Bioactive compounds extracted from Ecklonia cava by using enzymatic hydrolysis protects high glucose-induced damage in INS-1 pancreatic β-cells. Appl Biochem Biotechnol (2012) 167:1973-1985.
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Yeo AR, Lee J, Tae IH, Park SR, Cho YH, Lee BH, Shin HC, Kim SH, Yoo YC. Anti-hyperlipidemic effect of polyphenol extract (Seapolynol™) and dieckol isolated from Ecklonia cava in in vivo and in vitro models. Prev Nutr Food Sci (2012) 17:1-7.
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Moon HE, Islam N, Ahn BR, Chowdhury SS, Sohn HS, Jung HA, Choi JS. Protein tyrosine phosphatase 1B and α-glucosidase inhibitory phlorotannins from edible brown algae, Ecklonia stolonifera and Eisenia bicyclis. Biosci Biotechnol Biochem (2011) 75:1472-1480.
Yokogawa K, Matsui-Yuasa I, Tamura A, Terada M, Kojima-Yuasa A. Inhibitory effects of Ecklonia cava extract on high glucose-induced hepatic stellate cell activation. Mar Drugs (2011) 9:2793-2808.
Kang C, Jin YB, Lee H, Cha M, Sohn ET, Moon J, Park C, Chun S, Jung ES, Hong JS, Kim SB, Kim JS, Kim E. Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways. Food Chem Toxicol (2010) 48:509-516.
Kim SK, Kong CS. Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes. Chem Biol Interact (2010) 186:24-29.
Kong CS, Kim JA, Ahn BN, Vo TS, Yoon NY, Kim SK. 1-(3′,5′-dihydroxyphenoxy)-7-(2”,4”,6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin inhibits adipocyte differentiation of 3T3-L1 fibroblasts. Mar Biotechnol (NY) (2010) 12:299-307.
Lee SH, Park MH, Heo SJ, Kang SM, Ko SC, Han JS, Jeon YJ. Dieckol isolated from Ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice. Food Chem Toxicol (2010) 48:2633-2637.
Oh JK, Shin YO, Yoon JH, Kim SH, Shin HC, Hwang HJ. Effect of supplementation with Ecklonia cava polyphenol on endurance performance of college students. Int J Sport Nutr Exerc Metab (2010) 20:72-79.
Lee SH, Li Y, Karadeniz F, Kim MM, Kim SK. α-Glucosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga, Ecklonia cava. J Sci Food Agric (2009) 89:1552-1558.
Iwai K. Antidiabetic and antioxidant effects of polyphenols in brown alga Ecklonia stolonifera in genetically diabetic KK-Ay mice. Plant Foods Hum Nutr (2008) 63:163-169.
Yoon NY, Kim HR, Chung HY, Choi JS. Anti-hyperlipidemic effect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Arch Pharm Res (2008) 31:1564-1571.
Kim YC, An RB, Yoon NY, Nam TJ, Choi JS. Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in Hep G2 cells. Arch Pharm Res (2005) 28:1376-1380.
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